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Oncogene (2013) 32(26):31118.10.1038/onc.2012.435 154 MelmedSPolonskyKSLarsenPRKronenbergH

Consequently, zinc deficiency is common in vegans who exclude animal products, as well as in patients with nephropathies, malabsorptive gastrointestinal diseases, cancer and diabetes

Important safety considerations include risk of pancreatitis (seek urgent medical care if you experience severe, persistent abdominal pain), gallbladder problems, and potential hypoglycaemia in people with diabetes taking insulin or sulfonylureas

That said, extensive research including controlled studies and mechanistic research shows that ALA and ALC affect mitochondrial function, antioxidant pathways, and nerve metabolism

Overall, they are considered well tolerated for most people